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KMID : 1134820160450070966
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 7 p.966 ~ p.972
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In Vitro Screening for Anti-Dementia Activities of Seaweed Extracts
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Son Hyun-Jung
Um Min-Young
Kim In-Ho
Cho Seung-Mock
Han Dae-Seok
Lee Chang-Ho
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Abstract
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We investigated that methanolic extracts of 20 kinds of seaweeds from Jeju Island for their antioxidant activities, acetylcholinesterase and β-secretase inhibitory activities, and neuronal survival in order to evaluate their potentials as anti-dementia agents. Ecklonia cava extracts had the highest total polyphenol content among the 20 seaweed extracts. The antioxidant activity of seaweed extracts was measured by using 2,2'-azino-bis-(3-ethylbenzothiazoline- 6-sulfonic acid) (ABTS) assay. It was found that Ecklonia kurome extracts had the highest ABTS scavenging activity (IC50=0.07±0.01 mg/mL). As a result, Ecklonia cava, Ecklonia kurome, and Myelophycus simplex extracts were found to be the most effective in terms of acetylcholinesterase inhibitory activity. In the β-secretase activity assay, Ecklonia cava and Ecklonia kurome extracts were effectively inhibited (84.41±1.70% and 81.17±2.43%, respectively). As expected, neuronal cell death induced by H2O2 in SH-SY5Y cells was diminished by Ecklonia cava, Ecklonia kurome, and Sargassum yezoense extracts. Taken together, these results showed that Ecklonia cava extract has potential anti-dementia activity, which suggests that it might provide an effective strategy for improving dementia.
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KEYWORD
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seaweed extracts, Alzheimer's disease, acetylcholinesterase, antioxidant activity, neuroprotective effect
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